Modulation of lipid peroxidation and energy metabolism in the gastric mucosa as a mechanism of antiulcer activity of placental cryoextract in the healing of stress-induced ulcers

Background. Peptic ulcer disease has a leading place in the overall structure of digestive diseases: its prevalence is 6.00–10.0 % population developed countries, and mortality ranges from 6 to 9.7 per 100 thousand population. An important etiological factor this pathology neuropsychological background, prima­rily stress, which under repeated exposure becomes initiating physiological imbalance between elements aggression protection gastric mucosa. The purpose was establish mechanisms protective activity placental cryoextract based on biochemical indicators lipid peroxidation antioxidant mucosa model stress-induced erosive-ulcerative damage. Materials methods. Stu­dies were performed 28 nonlinear laboratory male rats weig­hing 200–220 g. Stress-induced modeled water-immobilization stress according K.Y. Takagi et al. In mucosa, content reactants with thiobarbituric acid determined spectrophotometrically by method T. Asakawa al., catalase acti­vity — M.A. Korolyuk reduced glutathione E.D. Beutler level adenyl nucleotides using chromatographic me­thod. Energy charge calculated D.E. Atkinson equation. ­Results. prophylactic five-day use led decrease severity ener­gy Thus, it found that who received had statistically significant (p < 0.001) increase adenosine triphosphate 73.3 %, an diphosphate 37.3 monophosphate 47.6 energy 35.1 compared exposed without correction (control group). It shown antioxidant-prooxidant index 3.1 times versus control group, (26.60 ± 0.96) (8.60 0.43), respectively. Conclusions. Prophylactic administration leads restoration balance system and, accor­dingly, animals. Inhibition hyperactivation one antiulcer activity.